Diresorcin isatin



Patented Dec. 26, 1933 UNITED STATES PATENT- OFFICE DIRESORCIN ISATIN Walter G. Christiansen, Glen Ridge, N. J., and

Sidney E. Harris, Bro

E. R. Squibb & Sons, Brooklyn, N. Y., a notation of New York Application March 9, 1932 Serial No. 597,801

No Drawing.

3 Claims.

This invention relates to direscrcin isatin.

We have found this compound to be important as an intermediate in the preparation of valuable therapeutic compounds.

Diresorcin isatin may be prepared by suspending 5.6 gms. of isatin and 8.2 gms. of resorcin in I 50 cc. of glacial acetic acid. The mixture is thoroughly agitated, then concentrated sulfuric acid is added slowly, drop by drop, until the mixture is homogeneous and the isatin color is entirely replaced by a clear deep red. The mixture is poured into 500, cc. of cold water and a small quantity of sodium acetate is added. After standing for some time the precipitated diresorcin isatin is filtered off, washed with water and dried at 60 to 80 C. The white solid so formed melts above 270 C.

On analysis, the compound has been found to have the formula,

CaoHrsNOs and is, therefore, represented by the iormulai HEP-(i=0 a0 tn The substance readily loses water when acted upon by dehydrating agents forming a closed ring 40 structure:

oklyn, N. Y., assignors to cor- 8. The compound:

NH'G=OV WALTER G. CHRISTIANSEN. SIDNEY E. HARRIS.

where R andR' are both OH, or jointly --0--.

2 The compound:

NHO==O 

